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Phenobarbital lowers the plasma amounts of dicumarol (identify Earlier employed: bishydroxycoumarin) and triggers a lessen in anticoagulant exercise as calculated through the prothrombin time. Barbiturates can induce hepatic microsomal enzymes causing enhanced metabolism and lowered anticoagulant response of oral anticoagulants (e.
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Maximal CNS despair might not manifest until 15 minutes or even more immediately after IV administration for phenobarbital sodium.
Some published research in little ones advise that comparable deficits may perhaps manifest soon after repeated or extended exposures to anesthetic brokers early in life and should result in adverse cognitive or behavioral effects.
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